Greasy Fork

MegaUp.net is a den of the worst parts of the web. Its "anti-adblock" is so bad that it detects that an ad blocker is installed on a stock standard install of Firefox, Chrome, and Microsoft Edge without ANY extensions installed. Furthermore, you'd be ill-advised to visit the site without an ad blocker. It has the MOST intrusive, virus ridden (every one of their ads attempts to fool the user into installing a fake browser/Windows/etc update and/or tries to fool the user into believing the ad's malware laden download is the actual file you are trying to download). In other words, the website is a minefield and you should avoid it at all costs. If however you need a file that is hosted on the site, this script DOES actually work (at least right now) and I want to express my gratitude to the script author for sharing it with the rest of us. Great job!

That site is FULL of clickjackers, floating ads, and other user-unfriendly advertisements preventing the user from using the site (unless, like you said, use an adblocker (if it can bypass the site's measures) or using the devtools's web inspector). Most of them are scams (tech support scams, flash update scams, pages asking user to install an extension to continue, fake skip ad button despite no accompanying video that it is on, a pornographic chat screen mimicking a text message) and malware.

I can't even fathom how does this site still exists even today. And why are some people still using it. Many websites that go this route (typically adult sites, "sail the high seas" sites, and not just megaup, but other filehosting sites) would die from a vicious cycle of putting more ads or making them even more intrusive, users go harder on the ad blocker, site loses money, and repeat. These are the types of websites with such ads are million times worse than Fandom (wiki farm site).

Ads shouldn't:
(1) force user and/or their browser to open an ad page in any way (tabs, separate browser window) to access content (shame on you mediafire), and;
(2) hinder or outright prevent them from accessing content (overuse of interstitial/fullscreen ads, or any ad that covers the content, screen-following or not, and being closable or not). If it requires additional user input, that's off-limits.