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Chrome v77.0.3865.120 Official build x64 and v2.24 of Instagram Reloaded on Tampermonkey (Win 10 x64). I've disabled all extensions and scripts, and checked that my shift keys are working properly.
Alt+F just opens Chrome's menu and shift+click doesn't do anything. If you click fast enough it acts as a double click and "likes" the current image. Same behaviour with alt+click.